The International Space Station (ISS) is part of the human endeavor to explore and use Space. It requires to acquire the capability of living in Space, but it also offers the possibility of using the space environment to improve human capabilities. The main peculiarity of space is the absence of weight; it is necessary for humans in space to learn how to cope with it, but it is also known to be a major advantage for many activities which on Earth are limited precisely by the unavoidable presence of the local gravitational force ("1-g" ground environment as opposed to the "0-g" space environment). In some cases, e.g. when the goal is to understand the behavior of the human body in absence of weight, the ISS as such is the perfect environment. However, there are many activities typical of the applied sciences which require, in addition to absence of weight, also a low level of residual disturbances, sometimes also in a wide frequency range. Material and fluid sciences are typical examples. Growing crystals (e.g. crystals of Silicium) with low levels of impurities is regarded as a major task (mostly for the computer industry), and crystal growth is known to be influenced not only by local gravity but also by the residual, smaller disturbances such as seismic noise on Earth and vibration noise in the space environment. Material sciences are potentially destined to take great advantage from the availability of space structures such as the ISS, but they cannot use space structures as such: they can take advantage of the ISS only provided that residual disturbances on board the ISS are significantly reduced, thus enabling what is widely known as science and applications in "microgravity" which so far is not fully available. This is the goal of the PGB (Pico Gravity Box) passive/active vibration isolation system proposed here, where we have chosen the words "Pico Gravity" instead of "Micro Gravity" to stress the point that residual disturbances are really very very small